The combination of simplex lattice design and chemometrics in the formulation of green tea leaves as transdermal matrix patch

Aim : This study was aimed to formulate a transdermal matrix patch using green tea leaf extract. Materials and methods The formulation optimized by the simplex lattice design method. correlation between responses analyzed chemometrics. observed were: 1. physical properties of patch, 2. percentage dissolution efficiency catechins, caffeine, epigallocatechin gallate released from patch. determination drug release kinetics based on curve-fitting analysis zero-order, first-order, Higuchi, Korsmeyer-Peppas models. Results results showed that optimal formula obtained mixture HPMC K100, K4M, PEG 400 at ratio 4.0: 4.5: 0.5. principal component (PCA) %DE 300 values catechin caffeine positively correlate. A similar condition weight thickness matrix. Drug follows model.